Traumatic Brain Injury History and Progression from Mild Cognitive Impairment
 
   Lead Investigator:    Christian LoBue
   Institution      :    UT Southwestern Medical Center
   E-Mail           :    christian.lobue@utsouthwestern.edu
   Proposal ID      :    601


   Publications:


1  LoBue C, Woon FL, Rossetti HC, Hynan LS, Hart J, Cullum CM
   Traumatic brain injury history and progression from mild cognitive impairment to Alzheimer disease
   Journal Article  Neuropsychology,32:401-409,2018,PMC5975979

   PUBLISHED



2  Pradeep T, Arun S, Richey L, LoBue C, Lyketsos CG, Kim P, Peters ME
   History of Traumatic Brain Injury Interferes with Accurate Diagnosis of Alzheimer's Dementia: a nation-wide case-control study
   Journal Article  Int Rev Psychiatry,32(1):61-70,2020,PMC6952566

   PUBLISHED



3  Wilmoth K, LoBue C, Clem MA, Reddy R, Hynan LS, Didehbani N, Bell K, Womack KB, Hart J, Jr., Batjer H, Cullum CM
   Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment
   Journal Article  Clin Neuropsychol,32:524-529,2018,PMC5851823

   PUBLISHED





   Proposal Description:
   Mild cognitive impairment (MCI) is often a prodromal stage of AD, where           cognitive deficits are greater than normal age-related changes but do not         reflect functional impairment. Approximately 12 of MCI subjects progress to AD    each year compared to 1-2 in the normal population. Little is known whether an    increased risk for cognitive decline or an earlier age of onset may also be       associated with MCI and traumatic brain injury (TBI), and no studies have         examined whether  a history of TBI may be associated with course of cognitive     decline or progression from MCI to AD. This study will seek to determine          whether a history of TBI has an association with course of cognitive decline or   progression from MCI to AD.